Article | . Vol. 19, Issue. 3
Factors affecting antibiotic prescription in dental outpatients - A nation-wide cohort study in Korea -



Department of Dental Hygiene, Shin-han University1




.. 408:419


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Objectives: The purpose of this study was to analyze the factors affecting antibiotic prescription in dental outpatients. Methods: The present study was conducted using data from the National Health Insurance Service – National Sample Cohort. We analyzed prescriptions issued in the dental outpatient department in 2015, for adults over 19 years of age. Antibiotic prescription rates and mean prescription days were analyzed by sex, age, insurance type, presence of diabetes mellitus and hypertension, season in treatment, type of dental institution, and location of dental institution. Multivariate logistic regression was also performed to analyze the factors affecting antibiotic prescription in dental outpatients. Results: A total of 257,038 prescriptions were analyzed. The mean prescription days of antibiotics in dental outpatients were 3.04±1.08 days, and the prescription rate was 93.0%. Two variables (presence of diabetes mellitus and insurance type) were excluded from the multivariate logistic regression analysis model because they did not significantly affect antibiotic prescription. The possibility of antibiotic prescription was higher in men ≥61 years of age and those with hypertension. Furthermore, antibiotics were most frequently prescribed in dental clinics rather than dental hospitals, and more frequently in Busan compared to other areas (p<0.001). Conclusions: Several factors were determined to affect antibiotic prescription, and detailed guidelines for consistent antibiotic prescription are needed.



1. Dar-Odeh N, Ryalat S, Shayyab M, Abu-Hammad O. Analysis of clinical records of dental patients attending Jordan university hospital: documentation of drug prescriptions and local anesthetic injections. Ther Clin Risk Manag 2008;4(5):1111-7. https://doi.org/10.2147/tcrm.s3727  

2. Palmer NA, Pealing R, Ireland RS, Martin MV. A study of therapeutic antibiotic prescribing in National Health Service General Dental Practice in England. Br Dent J 2000;198(10):554-8. https://doi.org/10.1038/sj.bdj.4800538a  

3. Yingling NM, Byrne BE, Hartwell GR. Antibiotic use by members of the American Association of Endodontists in the year 2000: report of a national survey. J Endod 2002;28(5):396-404. https://doi.org/10.1097/00004770-200205000-00012  

4. WHO. Antimicrobial resistance: global report on surveillance [Internet]. World Health Organization; 2014. [cited 2019 Mar 15]. Available from: https://www.who.int/drugresistance/documents/surveillancereport/en/.  

5. Choi JH. The meaning and impact of appropriate use of antibiotics. Infect Chemother 2012;44(5):331-7. https://doi.org/10.3947/ic.2012.44.5.331  

6. Lee JR, Kim YS, Chang WS, Park OS, Lee YK. Antimicrobial resistance of Staphylococcus aureus isolated from Korean oral cavity. Kor J Oral Maxillofac Pathol 2011;35:31-6.  

7. Cho HA, Kim SM, Shin H. Drug prescription rates in dental health services. J Korean Acad Oral Health 2014;38:212-9. https://doi.org/10.11149/jkaoh.2014.38.4.212   

8. Durkin MJ, Hsueh K, Sallah YH, Feng Q, Jafarzadeh SR, Munshi KD, et al. An evaluation of dental antibiotic prescribing practices in the United States. J Am Dent Assoc 2017;148(12):878-86. https://doi.org/10.1016/j.adaj.2017.07.019  

9. Al-Haroni M, Skaug N. Incidence of antibiotic prescribing in dental practice in Norway and its contribution to national consumption. J Antimicrob Chemother 2007;59(6):1161-6. https://doi.org/10.1093/jac/dkm090  

10.  Pipalova R, Vlcek J, Slezak R. The trends in antibiotic use by general dental practitioners in the Czech Republic (2006–2012). Int Dent J 2014;64(3):138-43. https://doi.org/10.1111/idj.12089  

11. Marra F, George D, Chong M, Sutherland S, Patrick DM. Antibiotic prescribing by dentists has increased: Why? J Am Dent Assoc 2016;147(5):320-7. https://doi.org/10.1016/j.adaj.2015.12.014   

12. Halling F, Neff A, Heymann P, Ziebart T. Trends in antibiotic prescribing by dental practitioners in Germany. J Craniomaxillofac Surg 2017;45(11):1954-9. https://doi.org/10.1016/j.jcms.2017.08.010  

13. Oberoi SS, Dhingra C, Sharma G, Sardana D. Antibiotics in dental practice: how justified are we. Int Dent J 2015;65(1):4-10. https://doi.org/10.1111/idj.12146   

14. Cope AL, Francis NA, Wood F, Chestnutt IG. Antibiotic prescribing in UK general dental practice: a cross‐sectional study. Community Dent Oral Epidemiol 2016;44(2):145-53. https://doi.org/10.1111/cdoe.12199  

15. Kim H, Kim MK, Choi H. Factors affecting the rate of antibiotic prescription in dental practices. J Korean Acad Oral Health 2017;41:28-35. https://doi.org/10.11149/jkaoh.2017.41.1.28   

16. Lee J, Lee JS, Park SH, Shin SA, Kim K. Cohort profile: The national health insurance service–national sample cohort (NHIS-NSC), South Korea. Int J Epidemiol 2017;46(2):e15. https://doi.org/10.1093/ije/dyv319  

17. Choi WJ, Yim E, Kim TH, Suh HS, Choi KC, Chung W. Analysis of factors related to the prescription of antibiotics for the acute upper respiratory infection. Health Policy and Management 2015;25:256-63. https://doi.org/10.4332/kjhpa.2015.25.4.256  

18. Gong MJ. Clinical department prescription drugs characteristics of Acute upper respiratory tract infection disease [Master’s thesis]. Pusan: Univ. of Catholic, 2016.   

19. Kanuga S. Short-term oral antibiotics may be as effective as the standard course of penicillin for children with acuteStreptococcal pharyngitis . J Am Dent Assoc 2015;146(12):927-8. https://doi.org/10.1016/j.adaj.2015.09.017  

20. el Moussaoui R, de Borgie CA, van den Broek P, Hustinx WN, Bresser P, van den Berk GE, et al. Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia: randomised, double blind study. BMJ 2006;332(7554):1355. https://doi.org/10.1136/bmj.332.7554.1355   

21. Colquhoun D. An investigation of the false discovery rate and the misinterpretation of p-values. R Soc Open Sci 2014;1(3):140216. https://doi.org/10.1098/rsos.140216   

22. Cho HJ, Hong SJ, Park S. Knowledge and beliefs of primary care physicians, pharmacists, and parents on antibiotic use for the pediatric common cold. Soc Sci Med 2004;58(3):623-9. https://doi.org/10.1016/s0277-9536(03)00231-4  

23. Kim NS, Jang SN, Jang SM. Factors influencing antibiotics prescribing of primary health physicians in acute upper respiratory infections. J Prev Med Public Health 2005;38(1):1-8.   

24. Alrashdan M, Choung HU, Pang KM, Park JC, Kim SM, Kim MJ, et al. Literature review of antibiotics prescription in general dental and oral-maxillofacial surgical practice. J Korean Assoc Oral Maxillofac Surg 2009;35(3):164-9.  

25. Tong DC, Rothwell BR. Antibiotic prophylaxis in dentistry: a review and practice recommendations. J Am Dent Assoc 2000;131(3):366-74. https://doi.org/10.14219/jada.archive.2000.0191   



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